December 18, 2018

2018 Research Highlights 鈥� Promising Medical Advances

Findings with Potential for Enhancing Human Health

With 51视频 support, scientists across the United States and around the world conduct wide-ranging research to discover ways to enhance health, lengthen life, and reduce illness and disability. Groundbreaking 51视频-funded research often receives top scientific honors. In 2018, these honors included two 51视频-supported scientists who earned Nobel Prizes and three 51视频-funded researchers who earned prestigious Lasker Awards. Here鈥檚 just a small sample of the 51视频-supported research accomplishments in 2018. For more health and medical research findings from 51视频, visit .

Full 2018 51视频 Research Highlights List

Test vaccine active against many HIV strains

Researchers haven鈥檛 been able to create an effective HIV vaccine, in part because there are many different strains of the virus. 51视频 scientists have been developing a vaccine to target a part of the virus that鈥檚 thought to be similar across most HIV strains. When tested in animals, this vaccine prompted the immune system to form antibodies that could neutralize dozens of HIV strains. A small study of the test vaccine in people is expected to begin in late 2019.

Blood test detects several cancer types

Cancer treatment is more likely to be successful when the disease is detected early. Researchers have been working to develop tests that detect bits of tumor material in blood, urine, or saliva. One team developed a blood test that can detect signs of eight common solid tumors. With further development, this type of test could allow for earlier detection and treatment of several types of cancer.

Gut microbe drives autoimmunity

Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice that are prone to such disease. The bacteria crossed the gut barrier and moved into the lymph nodes and liver to provoke an autoimmune response. The researchers found the same microbe in liver biopsies from people with autoimmune diseases, but not from healthy liver transplant donors. The results suggest new avenues for treating debilitating and potentially lethal autoimmune diseases.

Wearable ultrasound patch tracks blood pressure

High blood pressure, or hypertension鈥攁 condition that can lead to heart attack, stroke, kidney disease, and other health problems鈥攗sually doesn鈥檛 cause warning symptoms, so many people don鈥檛 know they have it. A blood pressure test is the only way to detect it. Researchers are engineering a blood pressure sensor that uses ultrasound technology within a flexible skin patch. After further development and testing, the technology may eventually replace other methods of monitoring blood pressure.

Appendix linked to toxic Parkinson鈥檚 protein

In Parkinson鈥檚 disease, many brain cells contain unusual clumps of the protein alpha-synuclein. These clumps are thought to be toxic to the cells and lead to their death. This protein has also been shown to accumulate in the gut of Parkinson鈥檚 patients. Researchers discovered that people who鈥檇 had their appendix removed had a lower chance of developing Parkinson鈥檚 disease. The study suggests that the toxic protein buildup that鈥檚 linked to Parkinson鈥檚 may begin in the appendix.

Impaired brain drainage in aging and Alzheimer鈥檚

Vessels that allow waste products to drain out of the brain were only recently discovered. A new study found that these waste-clearing vessels don鈥檛 work as well in older mice, which leads to waste buildup. When the scientists enhanced vessel drainage in older mice, the animals鈥� cognitive abilities improved. In contrast, disrupting these vessels increased buildup of Alzheimer鈥檚 disease-related proteins. These results suggest a possible way to combat the cognitive decline seen in aging and age-related diseases.

Regrowing neurons across scarred spinal tissue

Spinal cord damage can lead to a loss of sensation and paralysis below the injury site. Scientists have long thought that the scar that forms after a spinal cord injury actively prevents the regrowth of damaged neurons, the cells that carry messages to and from the brain. Researchers were able to devise a three-pronged approach to stimulate the growth of neurons across scarred spinal tissue in rodents. The findings could help scientists develop treatments for spinal cord injury.

Vaccine protects animals against anthrax and plague

Certain microbes pose a risk to national security because a terrorist could release them to infect and sicken the public. Researchers developed a way to engineer a vaccine that protected animals from both anthrax and plague, two major bioterrorism agents. After more development and testing, the approach could be used to protect people from these and other diseases that pose a public health threat.