51��Ƶ

Friday, November 2, 2018

51��Ƶ greatly expands investment in BRAIN Initiative

The National Institutes of Health announces funding of more than 200 new awards, totaling over $220 million, through the , an exciting trans-agency effort to arm researchers with revolutionary tools to fundamentally understand the neural circuits that underlie the healthy and diseased brain. Supported by the Congress through both the regular appropriations process and the 21^st Century Cures Act, this brings the total 2018 support for the program to more than $400 million, which is 50 percent more than the amount spent last year. Many of the new awards explore the human brain directly.  Furthermore, the 51��Ƶ is trying to leverage some BRAIN Initiative advances to help tackle the pain and opioid crisis.

“Brain diseases are some of the greatest mysteries in modern medicine. These projects will provide new tools and knowledge needed to discover answers for some of the most difficult neurological and neuropsychiatric disorders,” said 51��Ƶ Director Francis S. Collins, M.D., Ph.D.

Examples of these new awards include the creation of a ; the development of a ; and the testing of noninvasive brain stimulation devices for treating , , and other brain diseases. All these awards can be found on the .

Through this expanded program, more than to support the projects of  upwards of 500 investigators representing fields as diverse as engineering and psychology. Many of the awards fund the development of new tools and technologies to capture a dynamic view of brain circuits in action, including the development of and the creation of an .

“New tools to map the brain deepen our understanding of how circuit activity relates to behavior, said Joshua A. Gordon, M.D., Ph.D., director of 51��Ƶ’s National Institute of Mental Health. “The BRAIN Initiative is laying the foundation for improved ways to target brain circuits disrupted in brain disorders.”

In response to the opioid crisis, 51��Ƶ is trying . This could include using innovative imaging and -omics neurotechnologies to search for new nonaddictive treatments for pain as part of the of 51��Ƶ’s HEAL (Helping to End Addiction Long-term) Initiative.

“Our country is in the midst of a serious public health challenge from drug use. We hope the advances made by BRAIN Initiative researchers will help us rapidly solve the problems we face in treating pain and opioid addiction,” said Walter J. Koroshetz, M.D., director of 51��Ƶ’s National Institute of Neurological Disorders and Stroke.

Launched in 2013, the BRAIN Initiative is a large-scale effort to accelerate neuroscience research by equipping researchers with the tools and insights necessary for treating a wide variety of brain disorders, including Alzheimer’s disease, schizophrenia, autism, epilepsy, and traumatic brain injury. Since then, BRAIN Initiative-funded researchers have ; mapped out the neural circuit activity that controls thirst and drinking and reactions to threats; tested theories about how ; ; created a self-tuning deep brain stimulation device for treating Parkinson’s disease; and . In addition, researchers used a tool developed through the BRAIN Initiative, called Drop-seq, to investigate the effects of concussions on individual brain cells, which pointed to novel treatments. These are just a few of many examples of how the BRAIN Initiative is catalyzing rapid advances in neuroscience.

® is managed by 10 institutes whose missions and current research portfolios complement the goals of the BRAIN Initiative: National Center for Complementary and Integrative Health, National Eye Institute, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute on Drug Abuse, National Institute on Deafness and other Communication Disorders, National Institute of Mental Health, and National Institute of Neurological Disorders and Stroke.

About the National Institutes of Health (51��Ƶ): 51��Ƶ, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. 51��Ƶ is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about 51��Ƶ and its programs, visit www.nih.gov.

51��Ƶ…Turning Discovery Into Health^®